Canadian Blood and Marrow Transplant Group
Cure Stems From Here
Meetings
8th Biennial CBMTG Conference
Delegates from Canada and around the world attended the 8th Biennial CBMTG Conference held from May 29 - June 2, 2002 in beautiful Halifax, Nova Scotia.
Pre-Conference Sessions
Wednesday, May 29
11:00 am – 10:00 pm – Registration Open
12:30 pm – 10:00 pm
CBMTG Clinical Trials Network Strategy Meeting: Preparing a Grant Proposal to CIHR
[By Invitation Only]
CBMTG 2002 Conference Day One
Thursday, May 30
Thursday Committee Meetings
8:45 am – 9:45 am -- CBMTG Clinical Trials Network Supportive Care Strategy Subcommittee Meeting [By Invitation Only]
8:45 am – 9:45 am -- CBMTG Clinical Trials Network Data Management Subcommittee Meeting [By Invitation Only]
9:45 am – 10:45 am -- CBMTG Clinical Trials Network Stem Cell Sources Strategy Subcommittee Meeting [By Invitation Only]
9:45 am – 10:45 am -- CBMTG Clinical Trials Network Preparative Regimens Strategy Subcommittee Meeting [By Invitation Only]
11:00 am – 12:00 noon -- CBMTG Clinical Trials Network General Meeting: Data Management, Data Monitoring, Funding, Summary of May 29 Clinical Trials Strategy Meeting [By Invitation Only]
1:30 pm – 5:30 pm – BMT Laboratory Technologists Meeting [By Invitation Only]
7:00 pm – 10:30 pm -- Transplant Registry Working Meeting [By Invitation Only]
7:00 am – 8:00 pm – Registration Open
7:30 am – 8:30 am -- Breakfast
8:30 am – 8:45 am – Welcome
Session I
Food for Thought: Assessment of the Oral Cavity and Nutritional Issues in BMT Patients
Chairs: Jane Palmer & Cathy Schwindt
8:45 am – 9:25 am
Oral mucosal lesions in BMT patients
Michele Williams
9:25 am – 10:20 am
Nutritional support in HSCT: Where is the evidence?
Sheryl McDiarmid
David Armstrong
Ginette Caron
10:20 am – 10:35 am -- Break
Session II
Concurrent Workshops
10:35 am – 12:00 noon
Workshop A: Sexual health of BMT patients and their partners
Terry Sveinson
10:35 am – 12:00 noon
Workshop B: Helping parents to explain serious illness and death to children
Joan Hamilton
Luncheon Symposium
Progress and Challenges in the Management of
Cytomegalovirus (CMV) Infection and Disease
Chair: Irwin Walker
12:00 noon – 1:30 pm
Testing of CMV viral load and antiviral drug resistance to CMV in stem cell transplant recipients
Guy Boivin
Treatment strategies for CMV in stem cell transplantation
Irwin Walker
Oral valganciclovir: A new option for CMV
Atul Humar
Supported by an unrestricted educational grant from Hoffmann-La Roche
Session III
Fertility, Menopause and Osteoporosis
Chairs: Stephen Couban & Jo-Ann Edwards
1:30 pm – 2:10 pm
Fertility and bone marrow transplantation
Christine M. Derzko
Jeffrey H. Lipton
2:10 pm – 2:50 pm
Medically-induced menopause and osteoporosis
Richard S. Boroditsky
2:50 pm – 3:05 pm -- Break
Session IV
Higher Plains: Conflicts and Dilemmas
Chairs: Conrad Fernandez & Donna Woloschuk
3:05 pm – 3:45 pm
When the team doesn’t get along: A primer on conflict resolution
Roy Johnson
3:45 pm – 4:25 pm
Ethical dilemmas in bone marrow transplantation
Jeremy Sugarman
4:45 pm – 5:45 pm
Executive & Sponsor Reception
[By Invitation Only -- Executive Committee, Advisory Board and Conference Sponsors]
5:45 pm – 7:15 pm
Welcome Reception
Supported by Hoffmann-La Roche
CBMTG 2002 Conference Day Two
Friday, May 31
Friday Committee Meetings
12:15 pm – 2:00 pm -- BMT Coordinators’ Lunch [By Invitation Only]
Supported by the CBS Unrelated Bone Marrow Donor Registry
6:00 pm – 10:30 pm -- Transplant Registry Working Meeting [By Invitation Only]
7:00 am – 6:00 pm – Registration Open
Breakfast Symposium
Novel Conditioning Regimens in Bone Marrow Transplantation
Chair: James Russell
7:30 am – 9:00 am
Intravenous Busulfan and Fludarabine as conditioning for a reduced intensity stem cell transplantation
Edwin Alyea
Use of IV Busulfan in very small children
Martin Champagne
Update of a clinical and pharmacokinetic study of once daily intravenous busulfan
James Russell
Supported by an unrestricted educational grant from Orphan Medical Inc.
Session V
Concurrent Sessions
Session A: Myeloma
Chairs: Michael Crump & Stephen Couban
9:00 am – 9:40 am
Review of the French experience in clinical trials for myeloma
Michel Attal
9:40 am – 10:20 am
Future directions for high-dose therapy in the plasma cell dyscrasias: Myeloma, amyloidosis and Waldenstroms macroglobulinemia
Donna Reece
Session B: Pediatric Transplantation
Chairs: Conrad Fernandez & Michael Barnett
9:00 am – 9:40 am
Stem cell transplant for rheumatologic disease: A pediatric perspective
Nico Wulffraat
9:40 am – 10:20 am
Point-counterpoint forum on pediatric BMT for solid tumours
Caron Strahlendorf
Paul A. Meyers
10:20 am -- Break
Session VI
Stem Cells: Plasticity and Its Application
Chairs: Ronan Foley & Hans Messner
10:30 am – 11:00 am
Plasticity of stem cells and potential clinical applications
Connie J. Eaves
11:00 am – 11:30 am
Engineering stem cells
Mickie Bhatia
11:30 am – 12:00 noon
Stromal stem cells: Biology and clinical applications
Armand Keating
12:00 noon – 12:15 pm
Panel Discussion
Luncheon Symposium
Clinical and Biological Characterization of Mobilized Peripheral Blood Stem Cells: Clinical Implications and Future Directions
12:15 pm – 2:00 pm
Mobilization of stem cells with SCF/GCSF in Multiple Myeloma: How many stem cells do we really need?
Ian Chin-Yee
Characterization of primitive human hematopoietic cells from GCSF and SCF mobilized peripheral blood
Mickie Bhatia
Lymphocyte recovery following PBSCT for Multiple Myeloma: What impact does the CD34+ cell dose have?
Ronan Foley
Supported by an unrestricted educational grant from AMGEN Canada Inc.
Session VII
Gastrointestinal Considerations
Chairs: Donna Forrest & Irwin Walker
2:00 pm – 2:40 pm
The liver in BMT: Pre-transplant considerations and approaches to the diagnosis and management of VOD
George B. McDonald
2:40 pm – 3:20 pm
New agents in the treatment of mucositis
Eric J. Bow
3:20 pm -- Break
Session VIII
Research, Education & Program Development Presentations
Moderator: Stephen Couban
Chairs: Thomas Nevill, Jean Roy, James Russell & Donna Woloschuk
3:30 pm – 3:45 pm – Introduction
3:45 pm – 4:00 pm
Establishment of the reliability and validity of the WCCNR stomatitis staging system
Deborah Gue
4:00 pm – 4:15 pm
High frequency of clinical and molecular remissions associated with Rituximab immunotherapy following high dose therapy and autologous stem cell transplantation for mantle cell lymphoma
Joy Mangel
4:15 pm – 4:30 pm
Early introduction of Tacrolimus followed by Mofetil in non-myeloablative hematopoietic stem cell allotransplantation (NMA-HSCAT) leads to prompt engraftment with little acute GVHD
Richard Le Blanc
4:30 pm – 4:45 pm
Photodynamic cell therapy preferentially eliminates B-lineage lymphoma cells over T cells, and preserves a hierarchy of myeloid and erythroid progenitors
Denis-Claude Roy
4:45 pm – 5:00 pm
Vaccination with autologous CD34+ derived dendritic cells transduced with an adenovirus expressing human GP100 in patients with metastatic melanoma
Ronan Foley
5:00 pm – 5:15 pm
Ten-year follow-up of patients having received high-dose chemotherapy and autologous stem cell transplantation for primary refractory or relapsed Hodgkin’s disease
Julye Lavoie
5:15 pm -- 5:30 pm
A ten year single centre study of autologous stem cell transplantation in relapsed advanced follicular non-Hodgkin’s lymphoma
Mitchell Sabloff
5:30 pm -- 5:45 pm
A prospective, randomized clinical trial of Valacyclovir (VAL) vs. Acyclovir (ACV) in the prevention of mucocutaneous herpes simplex virus (HSV) infections in neutropenic patients
Dawn Warkentin
Supported by an unrestricted educational grant from Ortho Biotech Canada
CBMTG 2002 Conference Day Three
Saturday, June 1
Breakfast Symposium
Moderator: Eric Bow
7:30 am – 9:00 am
What’s new in prevention, diagnosis and treatment of fungal infections
Kieren Marr
Supported by an unrestricted educational grant from Fujisawa Canada
Session IX
Haploidentical Transplants
Chairs: Ronan Foley & Denis-Claude Roy
9:00 am – 9:30 am
Haploidentical transplants: Update on the Italian experience
Massimo F. Martelli
9:30 am – 9:55 am
Haploidentical transplants: Lessons from the Canadian experience
Irwin Walker
9:55 am – 10:20 am
CD34 enumeration in the new millenium: The current state of the art
D. Robert Sutherland
10:20 am -- Break
Session X
Autologous Transplantation for Non-Malignant Disease
Chairs: Michael Crump & Donna Forrest
10:35 am – 11:15 am
BMT for autoimmune disease
Alan Tyndall
11:15 am – 11:45 am
Bone marrow transplantation for Multiple Sclerosis
Harold A. Atkins
Luncheon Symposium
11:55 am – 12:15 pm
Neuroprotective effects of rhEPO
Hans Messner
12:15 pm – 12:35 pm
Transfusion requirements following allogeneic blood and marrow transplants
Anargyros Xenecostas
12:35 pm – 1:25 pm
Cord blood transplantation: Actual results and perspectives
Martin Champagne
Supported by an unrestricted educational grant from Ortho Biotech Canada
Session XI
New Frontiers in Allogeneic Transplantation
Chairs: Stephen Couban & Jean Roy
1:30 pm – 2:10 pm
Allogeneic transplantation for renal carcinoma
John Barrett
2:10 pm – 2:50 pm
Submyeloablative transplants for hematologic disease: A review
Michael Barnett
2:50 pm -- Break
Session XII
Graft-versus-Host Disease
Chairs: Michael Barnett & Hans Messner
3:05 pm – 3:45 pm
The role of cytokines in the pathogenesis of GVHD
James L.M. Ferrara
3:45 pm – 4:25 pm
New agents for GVHD
Kirk Schultz
4:25 pm – 4:45 pm
Closing remarks
Stephen Couban
5:00 pm – 6:00 pm
CBMTG Annual Business Meeting [Open to Individual CBMTG Members Only]
7:00 pm – 10:00 pm
Atlantic Lobster Feast
Supported by AMGEN Canada Inc.
Post-Conference Sessions
Sunday, June 2
9:00 am – 10:45 am
CBMTG Clinical Trials Network Update: Subcommittee Reports and Future Direction
Supported by an unrestricted educational grant from Ortho Biotech Canada
[Open – All Registrants Welcome]
11:00 am – 1:00 pm
CBMTG Board of Directors/Executive Committee Meeting
[By Invitation Only]
8th Biennial CBMTG Conference
Delegates from Canada and around the world attended the 8th Biennial CBMTG Conference held from May 29 - June 2, 2002 in beautiful Halifax, Nova Scotia.
Pre-Conference Sessions
Wednesday, May 29
11:00 am – 10:00 pm – Registration Open
12:30 pm – 10:00 pm
CBMTG Clinical Trials Network Strategy Meeting: Preparing a Grant Proposal to CIHR
[By Invitation Only]
CBMTG 2002 Conference Day One
Thursday, May 30
Thursday Committee Meetings
8:45 am – 9:45 am -- CBMTG Clinical Trials Network Supportive Care Strategy Subcommittee Meeting [By Invitation Only]
8:45 am – 9:45 am -- CBMTG Clinical Trials Network Data Management Subcommittee Meeting [By Invitation Only]
9:45 am – 10:45 am -- CBMTG Clinical Trials Network Stem Cell Sources Strategy Subcommittee Meeting [By Invitation Only]
9:45 am – 10:45 am -- CBMTG Clinical Trials Network Preparative Regimens Strategy Subcommittee Meeting [By Invitation Only]
11:00 am – 12:00 noon -- CBMTG Clinical Trials Network General Meeting: Data Management, Data Monitoring, Funding, Summary of May 29 Clinical Trials Strategy Meeting [By Invitation Only]
1:30 pm – 5:30 pm – BMT Laboratory Technologists Meeting [By Invitation Only]
7:00 pm – 10:30 pm -- Transplant Registry Working Meeting [By Invitation Only]
7:00 am – 8:00 pm – Registration Open
7:30 am – 8:30 am -- Breakfast
8:30 am – 8:45 am – Welcome
Session I
Food for Thought: Assessment of the Oral Cavity and Nutritional Issues in BMT Patients
Chairs: Jane Palmer & Cathy Schwindt
8:45 am – 9:25 am
Oral mucosal lesions in BMT patients
Michele Williams
9:25 am – 10:20 am
Nutritional support in HSCT: Where is the evidence?
Sheryl McDiarmid
David Armstrong
Ginette Caron
10:20 am – 10:35 am -- Break
Session II
Concurrent Workshops
10:35 am – 12:00 noon
Workshop A: Sexual health of BMT patients and their partners
Terry Sveinson
10:35 am – 12:00 noon
Workshop B: Helping parents to explain serious illness and death to children
Joan Hamilton
Luncheon Symposium
Progress and Challenges in the Management of
Cytomegalovirus (CMV) Infection and Disease
Chair: Irwin Walker
12:00 noon – 1:30 pm
Testing of CMV viral load and antiviral drug resistance to CMV in stem cell transplant recipients
Guy Boivin
Treatment strategies for CMV in stem cell transplantation
Irwin Walker
Oral valganciclovir: A new option for CMV
Atul Humar
Supported by an unrestricted educational grant from Hoffmann-La Roche
Session III
Fertility, Menopause and Osteoporosis
Chairs: Stephen Couban & Jo-Ann Edwards
1:30 pm – 2:10 pm
Fertility and bone marrow transplantation
Christine M. Derzko
Jeffrey H. Lipton
2:10 pm – 2:50 pm
Medically-induced menopause and osteoporosis
Richard S. Boroditsky
2:50 pm – 3:05 pm -- Break
Session IV
Higher Plains: Conflicts and Dilemmas
Chairs: Conrad Fernandez & Donna Woloschuk
3:05 pm – 3:45 pm
When the team doesn’t get along: A primer on conflict resolution
Roy Johnson
3:45 pm – 4:25 pm
Ethical dilemmas in bone marrow transplantation
Jeremy Sugarman
4:45 pm – 5:45 pm
Executive & Sponsor Reception
[By Invitation Only -- Executive Committee, Advisory Board and Conference Sponsors]
5:45 pm – 7:15 pm
Welcome Reception
Supported by Hoffmann-La Roche
CBMTG 2002 Conference Day Two
Friday, May 31
Friday Committee Meetings
12:15 pm – 2:00 pm -- BMT Coordinators’ Lunch [By Invitation Only]
Supported by the CBS Unrelated Bone Marrow Donor Registry
6:00 pm – 10:30 pm -- Transplant Registry Working Meeting [By Invitation Only]
7:00 am – 6:00 pm – Registration Open
Breakfast Symposium
Novel Conditioning Regimens in Bone Marrow Transplantation
Chair: James Russell
7:30 am – 9:00 am
Intravenous Busulfan and Fludarabine as conditioning for a reduced intensity stem cell transplantation
Edwin Alyea
Use of IV Busulfan in very small children
Martin Champagne
Update of a clinical and pharmacokinetic study of once daily intravenous busulfan
James Russell
Supported by an unrestricted educational grant from Orphan Medical Inc.
Session V
Concurrent Sessions
Session A: Myeloma
Chairs: Michael Crump & Stephen Couban
9:00 am – 9:40 am
Review of the French experience in clinical trials for myeloma
Michel Attal
9:40 am – 10:20 am
Future directions for high-dose therapy in the plasma cell dyscrasias: Myeloma, amyloidosis and Waldenstroms macroglobulinemia
Donna Reece
Session B: Pediatric Transplantation
Chairs: Conrad Fernandez & Michael Barnett
9:00 am – 9:40 am
Stem cell transplant for rheumatologic disease: A pediatric perspective
Nico Wulffraat
9:40 am – 10:20 am
Point-counterpoint forum on pediatric BMT for solid tumours
Caron Strahlendorf
Paul A. Meyers
10:20 am -- Break
Session VI
Stem Cells: Plasticity and Its Application
Chairs: Ronan Foley & Hans Messner
10:30 am – 11:00 am
Plasticity of stem cells and potential clinical applications
Connie J. Eaves
11:00 am – 11:30 am
Engineering stem cells
Mickie Bhatia
11:30 am – 12:00 noon
Stromal stem cells: Biology and clinical applications
Armand Keating
12:00 noon – 12:15 pm
Panel Discussion
Luncheon Symposium
Clinical and Biological Characterization of Mobilized Peripheral Blood Stem Cells: Clinical Implications and Future Directions
12:15 pm – 2:00 pm
Mobilization of stem cells with SCF/GCSF in Multiple Myeloma: How many stem cells do we really need?
Ian Chin-Yee
Characterization of primitive human hematopoietic cells from GCSF and SCF mobilized peripheral blood
Mickie Bhatia
Lymphocyte recovery following PBSCT for Multiple Myeloma: What impact does the CD34+ cell dose have?
Ronan Foley
Supported by an unrestricted educational grant from AMGEN Canada Inc.
Session VII
Gastrointestinal Considerations
Chairs: Donna Forrest & Irwin Walker
2:00 pm – 2:40 pm
The liver in BMT: Pre-transplant considerations and approaches to the diagnosis and management of VOD
George B. McDonald
2:40 pm – 3:20 pm
New agents in the treatment of mucositis
Eric J. Bow
3:20 pm -- Break
Session VIII
Research, Education & Program Development Presentations
Moderator: Stephen Couban
Chairs: Thomas Nevill, Jean Roy, James Russell & Donna Woloschuk
3:30 pm – 3:45 pm – Introduction
3:45 pm – 4:00 pm
Establishment of the reliability and validity of the WCCNR stomatitis staging system
Deborah Gue
4:00 pm – 4:15 pm
High frequency of clinical and molecular remissions associated with Rituximab immunotherapy following high dose therapy and autologous stem cell transplantation for mantle cell lymphoma
Joy Mangel
4:15 pm – 4:30 pm
Early introduction of Tacrolimus followed by Mofetil in non-myeloablative hematopoietic stem cell allotransplantation (NMA-HSCAT) leads to prompt engraftment with little acute GVHD
Richard Le Blanc
4:30 pm – 4:45 pm
Photodynamic cell therapy preferentially eliminates B-lineage lymphoma cells over T cells, and preserves a hierarchy of myeloid and erythroid progenitors
Denis-Claude Roy
4:45 pm – 5:00 pm
Vaccination with autologous CD34+ derived dendritic cells transduced with an adenovirus expressing human GP100 in patients with metastatic melanoma
Ronan Foley
5:00 pm – 5:15 pm
Ten-year follow-up of patients having received high-dose chemotherapy and autologous stem cell transplantation for primary refractory or relapsed Hodgkin’s disease
Julye Lavoie
5:15 pm -- 5:30 pm
A ten year single centre study of autologous stem cell transplantation in relapsed advanced follicular non-Hodgkin’s lymphoma
Mitchell Sabloff
5:30 pm -- 5:45 pm
A prospective, randomized clinical trial of Valacyclovir (VAL) vs. Acyclovir (ACV) in the prevention of mucocutaneous herpes simplex virus (HSV) infections in neutropenic patients
Dawn Warkentin
Supported by an unrestricted educational grant from Ortho Biotech Canada
CBMTG 2002 Conference Day Three
Saturday, June 1
Breakfast Symposium
Moderator: Eric Bow
7:30 am – 9:00 am
What’s new in prevention, diagnosis and treatment of fungal infections
Kieren Marr
Supported by an unrestricted educational grant from Fujisawa Canada
Session IX
Haploidentical Transplants
Chairs: Ronan Foley & Denis-Claude Roy
9:00 am – 9:30 am
Haploidentical transplants: Update on the Italian experience
Massimo F. Martelli
9:30 am – 9:55 am
Haploidentical transplants: Lessons from the Canadian experience
Irwin Walker
9:55 am – 10:20 am
CD34 enumeration in the new millenium: The current state of the art
D. Robert Sutherland
10:20 am -- Break
Session X
Autologous Transplantation for Non-Malignant Disease
Chairs: Michael Crump & Donna Forrest
10:35 am – 11:15 am
BMT for autoimmune disease
Alan Tyndall
11:15 am – 11:45 am
Bone marrow transplantation for Multiple Sclerosis
Harold A. Atkins
Luncheon Symposium
11:55 am – 12:15 pm
Neuroprotective effects of rhEPO
Hans Messner
12:15 pm – 12:35 pm
Transfusion requirements following allogeneic blood and marrow transplants
Anargyros Xenecostas
12:35 pm – 1:25 pm
Cord blood transplantation: Actual results and perspectives
Martin Champagne
Supported by an unrestricted educational grant from Ortho Biotech Canada
Session XI
New Frontiers in Allogeneic Transplantation
Chairs: Stephen Couban & Jean Roy
1:30 pm – 2:10 pm
Allogeneic transplantation for renal carcinoma
John Barrett
2:10 pm – 2:50 pm
Submyeloablative transplants for hematologic disease: A review
Michael Barnett
2:50 pm -- Break
Session XII
Graft-versus-Host Disease
Chairs: Michael Barnett & Hans Messner
3:05 pm – 3:45 pm
The role of cytokines in the pathogenesis of GVHD
James L.M. Ferrara
3:45 pm – 4:25 pm
New agents for GVHD
Kirk Schultz
4:25 pm – 4:45 pm
Closing remarks
Stephen Couban
5:00 pm – 6:00 pm
CBMTG Annual Business Meeting [Open to Individual CBMTG Members Only]
7:00 pm – 10:00 pm
Atlantic Lobster Feast
Supported by AMGEN Canada Inc.
Post-Conference Sessions
Sunday, June 2
9:00 am – 10:45 am
CBMTG Clinical Trials Network Update: Subcommittee Reports and Future Direction
Supported by an unrestricted educational grant from Ortho Biotech Canada
[Open – All Registrants Welcome]
11:00 am – 1:00 pm
CBMTG Board of Directors/Executive Committee Meeting
[By Invitation Only]